La Vanguardia publishes on Sunday 18th of December edition that The Center of Genetic Engineering and Biotecnology (CIGB-Biocubafarma) and our spin-off Nanomol Technologies start to clinically validate a new drug that aims at improving the healing of diabetic foot ulcers and preventing amputation.
N. Grimaldi, F. da Silva, N.V. Segovia, L. Ferrer-Tasies, S. Sala, J. Veciana,* and N. Ventosa*, Chem. Soc. Rev., 2016, 45, 6520—6545
ABSTRACT: This review presents the large plethora of lipid-based nanovescicles available nowadays, focusing on a new generation of non-liposomal L-NVs and showing their similarities and differences with respect to their ancestors (liposomes). Since the overspread of a nanomaterial to the market is also strongly dependent on the availability of technological-scale preparation methods, it also extensively review the current approaches exploited for L-NV production. The most cutting-edge approaches for their preparation based on compressed fluid (CF) technologies are highlighted since they show the potential to represent a game-change in the production of L-NVs, favoring their step from the bench to the market. Finally, this review briefly discusses L-NV applications in nanomedicine looking also for their future perspectives.
Francesca Leonardi, Stefano Casalini, Qiaoming Zhang, Sergi Galindo, Diego Gutiérrez, Marta Mas-Torrent. Advanced Materials. DOI: 10.1002/adma.201602479
This communication presents a novel electrolyte gated field-effect transistor based on a blend of dibenzo-tetrathiafulvalene and polystyrene deposited through bar-assisted meniscus shearing. This technique allows the fabrication of high performing electronic devices suitable for (bio)sensing applications and might capture industrial interest due to its scalability. The reported devices can operate in aqueous solution with comparable complexity to real samples.
Read full article here: http://onlinelibrary.wiley.com/doi/10.1002/adma.201602479/full
Nanomol group congratulates Dr. Ingrid Cabrera for the extraordinary award received for her PhD thesis. The thesis was supervised by Dra. Nora Ventosa and Prof. Jaume Veciana from Nanomol and it is entitled: “Nanovesicle-bioactive conjugates to be used as nanomedicines, prepared by a one-step scalable method using CO2-expanded solvents”.
Temiño, I., Del Pozo, F. G., Ajayakumar, M. R., Galindo, S., Puigdollers, J. and Mas-Torrent, M. (2016), Adv. Mater. Technol., 1600090. doi:10.1002/admt.201600090
In the last few years exciting advances have been achieved in developing printing techniques for organic semiconductors, and impressive mobility values have been reported for the resulting organic field-effect transistors (OFETs). However, not all these techniques are scalable and some of them require additional crystallization steps. This study reports on the fabrication of OFETs employing blends of four benchmark organic semiconductors with polystyrene and demonstrates that applying the same formulation and experimental conditions for printing them, highly reproducible and uniform crystalline films exhibiting high OFET performance are successfully achieved. It is noted that the mobility values achieved here are not the highest reported for the studied materials; however, they are state-of-the-art values and could be regarded as exceptional considering the low cost and fast speed of the fabrication process involved here.
Read more here: http://onlinelibrary.wiley.com/doi/10.1002/admt.201600090/full
M. Souto, H. B. Cui, M. Peña-Álvarez, V. G. Baonza, H. O. Jeschke, M. Tomic, R. Valentí, D. Blasi, I. Ratera, C. Rovira, J. Veciana
J. Am. Chem. Soc., 2016, 138 (36), pp 11517–11525DOI: 10.1021/jacs.6b02888
There is a growing interest in the development of single-component molecular conductors based on neutral organic radicals that are mainly formed by delocalized planar radicals, such as phenalenyl or thiazolyl radicals. However, there are no examples of systems based on non-planar and spin-localized C-centered radicals exhibiting electrical conductivity due to their large Coulomb energy (U) repulsion and narrow electronic bandwidth (W) that give rise to a Mott insulator behavior. Here we present a new type of non-planar neutral radical conductor attained by linking a tetrathiafulvalene (TTF) donor unit to a neutral polychlorotriphenylmethyl radical (PTM) with the important feature that the TTF unit enhances the overlap between the radical molecules as a consequence of short intermolecular S•••S interactions. This system becomes semiconducting upon the application of high pressure thanks to increased electronic bandwidth and charge reorganization opening the way to develop a new family of neutral radical conductors.
Li Yuan, Carlos Franco, Núria Crivillers, Marta Mas-Torrent, Liang Cao, C.S. Suchand Sangeeth, Concepció Rovira, Jaume Veciana, Christian A. Nijhuis
The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular tunnelling junctions, however, lack a gate electrode and suffer from Fermi-level pinning, making it difficult to control the energy-level alignment of the system. Here we report an enhancement of 2 orders of magnitude of the tunnelling current in a two terminal junction via chemical molecular orbital control, changing chemically the molecular component between a stable radical and its non-radical form without altering the supramolecular structure of the junction. Our findings demonstrate that the energy-level alignment in self-assembled monolayer-based junctions can be regulated by purely chemical modifications, which seems an attractive alternative to control the electrical properties of two terminal junctions.