"Nanomedicine" is a new word, but it is heard more and more. It is based on the administration of drugs by very small particles. They act directly on the specific site of the body, hence they are more effective. Using this methodology, Catalan researchers have found a new way to treat ulcers as the so-called "diabetic foot".
On June 9th 2015, 16th Symposium on rare diseases was held at the Institute of Catalan Studies, in which the results of 20 research projects funded by TV3 Marathon Foundation in its edition of 2009 were presented.
At the end of the ceremony, Dr. Gabriel Capellà, coordinator of the Scientific Advisory Board of the Foundation, mentioned five outstanding results from all developed projects. Among them, he spoke about the nanoconjugate developed by the NANOFABRY project through the collaboration of the CIBER-BBN groups headed by Dr. Simó Schwartz (VHIR), Prof Jaume Veciana and Dr. Nora Ventosa (Nanomol, CSIC), Dr. Miriam Royo (PCB-UB), and Dr. Pepe Corchero (IBB-UAB) for the treatment of the Fabry’s rare disease. This nanoconjugate is based on unilamellar lipid vesicles, or nanoliposomes, carrying the alpha-galactosidase enzyme as part of an enzyme replacement therapy for the Fabry’s disease. Dr. Capellà highlighted the submission and license of a patent protecting this nanoconjugate, recently licensed to the company Biopraxis Research, together with efforts done by the researchers to bring it to a regulatory pre-clinical stage, and the additional funding achieved by means of two new competitive projects, Lipocell and Terarmet, achieved by the same consortium.
Prof. Jaume Veciana has been named Scientific Director of the Singular Scientific Technological Infrastructures NANBIOSIS. This is one of the 29 ICTS which has been recently recognized by the Spanish Government (MINECO) comprising different units of the Biomedical Research Center in Bioingeneering, Biomaterials and Nanomedicine (CIBER-BBN) and the Centre for Minimal Invasive Surgery Jesus Uson (CCMIJU).NANBIOSIS provides a wide range of services for the production and characterization of nanomaterials, biomaterials and biomedical devices. This ICTS operates through a single contact point model and is organized into five platforms coordinating 27 service units that belong to CIBER-BBN and CCMIJU and that are distributed throughout the Spanish State (Alava, Badajoz, Barcelona , Caceres, Madrid, Valencia and Zaragoza) which receive support from more than 800 researchers from many different fields and with multidisciplinary experiences.
The Junta de Gobierno of the Real Sociedad Española de Química agreed to approve the Award for Excellence in Research RSEQ 2015 to Dr. Concepció Rovira Angulo in recognition of his outstanding contributions to chemistry, embodied in conceptual developments and studies on multifunctional molecular materials, particularly electronic and / or magnetic properties. His interdisciplinary research has a substantial effect on the development of nanoscience and molecular nanotechnology. Dr. Concepció Rovira is Research Professor of CSIC, under the Department of Molecular Nanoscience and Organic Materials Institute of Materials Science of Barcelona (ICMAB-CSIC). Recently, he has been awarded the "2013 Distinguished Women in Chemistry" IUPAC Prize. She is the author of over 300 publications, over 50 in the last five years, with very strong presence in the most important journals in the field of materials and notorious visibility in multidisciplinary chemistry with high impact factor with tens of publications (Journal of the American Chemical Society / Angewandte Chemie / Chemical Science / Nature Chemistry), 8 of them in the last five years. She is the author of numerous patents, including two international and another in operation. In the last five years it has been principal investigator of three European projects and other with state funding; in that five-year period, he has given more than 30 lectures at conferences and national and international centres of research. He has directed 13 doctoral theses, 3 in the last five years.
Riccardo Frisenda, Rocco Gaudenzi, Carlos Franco, Marta Mas-Torrent, Concepció Rovira, Jaume Veciana, Isaac Alcon, Stefan T. Bromley, Enrique Burzurí, Herre S. J. van der Zant
Nano Lett., 2015, 15 (5), pp 3109–3114
It is shown that the paramagnetism of the polychlorotriphenylmethyl (PTM) radical molecule in the form of a Kondo anomaly is preserved in two- and three-terminal solid-state devices, regardless of mechanical and electrostatic changes. Indeed, reported evidences demonstrate that the Kondo anomaly is robust under electrodes displacement and changes of the electrostatic environment pointing to a localized orbital in the radical as the source of magnetism. Strong support to this picture is provided by DFT calculations and measurements of the corresponding non-radical species. These results pave the way towards the use of all-organic neutral radical molecules in spintronics devices and open the door to further investigations into Kondo physics.
C. Franco, M. Mas-Torrent, A. Caballero, A. Espinosa, P. Molina, J. Veciana and C. RoviraChemistry A european Journal, 2015, 21, 5504 – 5509 DOI: 10.1002/chem.201405993
Two new pyrene-polychlorotriphenylmethyl (PTM) dyads and triads have been synthesized and characterized by optical, magnetic and electrochemical methods. The interplay between the different electronic states of the PTM moiety in the dyads and triads and the optical and magnetic properties of the molecules have been studied. The electronic spectra of the radicals show the intramolecular charge-transfer (ICT) transition at around 700 nm due to the acceptor character of the PTM radical. In the diamagnetic protonated derivatives, the fluorescence due to the pyrene is maintained, whereas in the radicals and the corresponding anions there is a clear quenching of the fluorescence. The redox activity of PTM radicals that are easily reduced to the corresponding carbanion has been exploited to fabricate electrochemical switches with optical and magnetic response.
In nature, cells react to complex mechanical and biological stimuli whose understanding is essential for tissue construction in regenerative medicine. A review how research progresses toward the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination has been published in Nanomedicinejournal.
Integrating mechanical and biological control of cell proliferation through bioinspired multieffector materials. J. Seras-Franzoso, W. I Tatkiewicz, E. Vazquez, E. García Fruitós, I. Ratera, J. Veciana, A. Villaverde.
Nanomedicine(Lond.) (2015) 10(5)