Materials characterized by exceptional properties attributable to their nanoscopic structure, can significantly contribute to the development of more efficient and less toxic drugs, more selective and sensitive disease-detection systems, and more effective tissue regeneration procedures. In the frame of several interdisciplinary projects, at Nanomol we conduct fundamental and applied research, to design and prepare new molecular nanostructured materials, which combine the intrinsic properties of molecules with the presence of different biological functions for the development of new strategies for diagnosis, of novel therapeutic formulations and of new scaffolds for targeting and cell proliferation in tissue engineering.
There are nowadays many expectations in the field of regenerative medicine and tissue engineering for new biocompatible materials that combine the intrinsic biological functions of natural tissues (biocompatibility, biological activity, etc..) with the typical properties of artificial materials (processability, low-cost, mechanical properties, etc). Recently our group has demonstrated that bottom-up decoration with bacterial inclusion bodies (IBs), which are mechanically stable, biocompatible particulate materials with genetically controlled nanoscale properties (including size, shape and stiffness), can modify the roughness of certain surfaces stimulating the colonization and proliferation of mammalian cells. We have provided an appropriate nano and micro engineering of cellular environments is a straightforward instrument for the promotion of cell growth and differentiation in tissue engineering. Such kind of advanced materials and others we work with could solve important problems that are poorly resolved or unresolved, in the field of implants and tissular regeneration.